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![]() ![]() In addition, the PIONEER trial met all key secondary endpoints, including significant improvements across all measures of mast cell burden. At 24 weeks, the control arm had a reduction of 9.2 points in mean TSS. The AYVAKIT arm had a reduction of 15.6 points in mean TSS at 24 weeks, which continued to deepen to 20.2 points at 48 weeks in patients who rolled over to the Part 3 open-label extension study. TSS was assessed by the Indolent SM Symptom Assessment Form (ISM-SAF). The trial, which was designed to assess AYVAKIT plus best available care versus placebo plus best available care (control arm), achieved its primary endpoint with a highly significant difference in the mean change in total symptom score (TSS) at 24 weeks (p=0.003). In addition, Blueprint Medicines plans to present detailed data from the PIONEER trial at an upcoming medical meeting. Food and Drug Administration (FDA) for AYVAKIT in non-advanced SM in the fourth quarter of 2022, with a subsequent submission of a type II variation marketing authorization application to the European Medicines Agency (EMA) anticipated in 2023. Based on these top-line data, Blueprint Medicines plans to submit a supplemental new drug application (sNDA) to the U.S. 17, 2022 /PRNewswire/ - Blueprint Medicines Corporation (NASDAQ: BPMC) today announced positive top-line results from the registrational Part 2 of the PIONEER clinical trial of AYVAKIT ® (avapritinib) in patients with non-advanced systemic mastocytosis (SM) demonstrating clinically meaningful and highly significant improvements across the primary and all key secondary endpoints, including patient-reported symptoms and objective measures of mast cell burden. Blueprint Medicines to host investor conference call and webcast today at 8:00 a.m. Plan to submit supplemental new drug application to FDA in fourth quarter of 2022. AYVAKIT had a favorable safety profile compared to the control arm, supporting potential for long-term treatment. Highly significant reductions across all objective measures of mast cell burden reinforce the disease modifying activity of AYVAKIT. AYVAKIT showed a superior mean change in total symptom score (p=0.003), compared to placebo plus best available care. ![]() ![]() ![]() O’er the land of the free and the home of the brave? O! say, does that Star-spangled Banner still* wave Gave proof through the night that our flag was still there O’er the ramparts we watched were so gallantly streaming,Īnd the rocket’s red glare, the bombs bursting in air, Whose broad stripes and bright stars through the perilous fight, What so proudly we hailed at the twilight’s last gleaming: O! say, can you see, by the dawn’s early light, But in that version, we only hear the first verse and chorus, which are not controversial: For many, the “Star Spangled Banner” is the patriotic song we hear before basketball, baseball, and football games. “The ‘Star Spangled Banner’ is not racist!” But, these days especially, as I know I have learned over and over, it’s important to listen when Black folks speak about these matters. Reading those words may make some bristle. ![]() Where the white gleam of our bright star is cast.“I don’t know how much you know about the current National Anthem,” Chanae says, “but it speaks despairingly about slaves and black people hired by the British side during the Revolutionary War.” We have come, treading our path through the blood of the slaughtered, We have come over a way that with tears has been watered, Sing a song full of the hope that the present has brought us,įacing the rising sun of our new day begunįelt in the days when hope unborn had died Ĭome to the place for which our fathers sighed? Sing a song full of the faith that the dark past has taught us, Laurin shared her thoughts about growing up with "Lift Every Voice and Sing," and about the role of music in her life. Laurin met with us on Zoom from her home in Philadelphia in front of a poster of Cicely Tyson, one of her role models. ![]() Consul to Venezuela from 1906 to 1913, and both became active Civil Rights leaders in the NAACP. James took a turn in the diplomatic core, serving as U.S. Rosamond Johnson moved to New York, where they wrote music for Broadway, and Black musical theater productions. The story of "Lift Every Voice and Sing" leads to the story of its creators. That's the only thing that keeps us going really-if we believe that there is a beautiful future to be had." "So whenever I sing it, I am thinking about my ancestors, and I'm thinking about, a dark past but a beautiful future. It's also looking towards the horizon and that's what I love about those lyrics." "It's not only revering, documenting, and validating the African American experience with those lyrics. The music is rousing the words are powerful. “It was one of those tunes I learned-even in middle school and high school, as I sang in those choirs- I would sing them in a choral style, I would sing them solo, I would with a gospel twinge, any program I was singing, maybe that song would be played, so I’ve sung it in so many different ways.” “It was just an institution in the Black community,” she says, describing it as woven throughout her childhood. “I’ve known it since I was a kid, probably five or six,” says singer Laurin Talese, who sang the song with The Philadelphia Orchestra on its digital stage series when live concerts were suspended, and then again to open the Orchestra’s 2021/2022 season. It became known as the Black National Anthem, and in 1919, the NAACP adopted the song, which was sung at school programs, social gatherings and civil rights marches throughout the 20th century. With its soaring melody and words of rejoicing and hope, freedom and faith, and overcoming a dark history of oppression-it spread through 20th century black communities, as people learned it, sang it and taught it to others. ![]() The title turned out to be prophetic, as this three-verse song took flight. In a ceremony celebrating the birth of Abraham Lincoln, a chorus of 500 school children sang out the compelling message of "Lift Every Voice and Sing," beginning with: It came to life in its first performance at the high school where James was principal. The now seminal anthem began as a poem-written in 1900 by James Weldon Johnson, a young writer working as a high school principal in Jacksonville, Florida-and set to music by his younger brother, composer J. ![]() ![]() ![]() NT Window WIndow Manufacturers in Mansfield Texas One of Dallas' Best Window and Door ManufacturersĪlside Ultra Max with SDL Grids Simulated Divided Lite Grids in Vinyl Replacement Windows Offer An Upscale Look Less frame means more light and better performance NT Window Single Hung and Double Hung Frame Sizes We sell more single hungs than double hungs as a rule. 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Click the pencil-like icon on the thumbnail to open the Video Editor window, where you can crop, trim, and rotate your videos, or apply effects, add watermarks and subtitles, etc. Step 3 Edit Videos with DVD Creator Freeware Alternative (Optional)Īll added files will be shown as thumbnails on the left panel. Hit this icon to open the search window and choose files present on your computer, or you can directly drag and drop files to the program. Step 2 Import Files to DVD Creator Freeware AlternativeĬlick the " + " button which reminds you to add videos. Then choose Create a DVD Video Disc option on the homepage. Steps on How to Create DVD with Wondershare DVD Creator Freeware Alternative Step 1 Launch DVD Creator Freeware AlternativeĪt the very beginning, you should download, install and launch the DVD creator freeware alternative on your PC/Mac first. In this article, the best 10 DVD creator freeware will be listed so that you can create DVD free.įree Download Free Download Watch Video Tutorial of DVD Creator Freeware Alternative If you want to achieve good results, then you need to get a software that will convert files and write them to your DVD, so that you know that information, be it a movie or documents or photos, is stored and accessible. However, it's not just as simple as buying a blank DVD and sticking it in your PC's CD drive. Sure, you can use the cloud – but is that really in your control? A DVD is easy to back up to once you know how, it takes up little-to-no space, and it's as good a back-up medium as you can get, provided you store and use it responsibly. That's the only way to ensure that you'll have a backup in case things go wrong. What happens when you want to watch a movie in a different room without a PC? 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I like how compact this blender is and easily fits into small spaces if you don’t have a lot of kitchen space. ![]() Beast Blender + Hydration System, Cloud White. It also comes with a glass bottle and infuser you can use to hold your smoothie or water. Hydration System: Borosilicate glass vessel, plastic and silicone lid with stainless steel infusion. ![]() It literally takes only 2 minutes for me to blend everything together. I have been using it since I bought it last month and enjoy making smoothies twice a day. I was skeptical, but when I blended my frozen fruits with all the ingredients for my s moothie, the blender is very powerful and you are able to either select pulse or blend for a whole minute to get less thick texture of the smoothie. I was excited to try this out considering I’ve seen many ads or commercials about this product on my social media. Shop Beast Blender Blend Smoothies and Shakes, Kitchen Countertop Design, 1000W (Cloud White) online at a best price in Canada. I’ve never owned anything like this before. This was my very first blender that I have ever bought. Product Dimensions: 4.92 x 4.92 x 15.75 inches Material: Stainless Steel, Aluminum, Plastic
![]() ![]() So while the Caramel Coconut Fudge Cookies are the priciest of the three, you'll be able to buy almost four boxes for the price of one! Talk about a steal. The value is good enough for a total savings of $11.71. Skip to Recipe Sharing a healthier take on the classic Girl Scout cookie with these Healthyish Homemade Samoas Cookies. This comes out to $3.29 for all three boxes compared to Girl Scout-branded cookies which sell for $5.00 a box. While they take some time to make, trust usthey're worth the wait. These copycat Girl Scout cookies are the ultimate indulgence. Soft and chewy cookies are topped with a caramely, crunchy coconut. 10 Amazing Girl Scout Cookie Copycats Inspired by: Caramel DeLites (aka Samoas) Coconut lovers, this one's for you. Cream shortening, sugar, milk, and vanilla in the bowl of an electric mixer. Hip2Save states Benton sells Fudge Mint Cookies (Thin Mints) for $0.95, Peanut Butter Filled Cookies (Tagalongs) for $0.95, and Caramel Coconut Fudge Cookies (Samoas) for $1.39. These Samoa Cookie-inspired Cookies are reminiscent of the Girl Scout Cookie Samoas. Sift together flour, baking powder, salt, and nutmeg in a medium-sized bowl. While it can't be said for certain whether or not a big brand manufactures Aldi's cookies, there is one thing you can be sure of –- Aldi's in-house cookie brand, Benton, is selling all of your favorite Girl Scout-inspired cookie flavors for a fraction of the cost. It’s a buttery, almost crumbly cookie that pairs perfectly with caramel and coconut. These bars are an easy-to-make copycat version of the coconut/caramel/chocolate/shortbread Girl Scout cookie. This includes anything from coffee, tea, ice cream, and, of course, cookies. What Type Of Cookies Are Samoas The base of Girl Scout Samoas cookies is shortbread. Samoas Bars - Just Like the Girl Scout Cookies. This is no surprise since Aldi is among a slew of retailers offering products sold by private label manufacturers, and according to Supermarket News, roughly 90% of Aldi products are privately labeled. While the most talked-about cookie might be the Thin Mint, the arguably most iconic of all is the sticky-sweet coconutty sensation known as the Samoa or Caramel DeLite, depending on where you live. ![]() ![]() ![]() Meanwhile, James followed suit with his own cryptic stare at Lee, who was decked out in Knicks blue and orange. ![]() Lees work has continually explored race relations, issues within the black community, the role of media in contemporary life, urban crime and poverty, and other political issues. NBA: Spike Lee Spends Big to Add Some Unbelievable Pieces of New York Knicks History to His Collection If Spike Lee cares about anything, its his beloved New York Knicks. New York entered the game having won 13 of its last 16 games.Īfter Los Angeles pulled away in overtime, cameras caught Davis smirking, with his hand up to his ear, while a poker-faced Lee looked his way. Shelton Jackson 'Spike' Lee (born March 20, 1957) is an American filmmaker and actor. 6 in the Eastern Conference after the loss. Knicks fans will get a chance to relive the team’s 1990s-era glory days, as Oscar-winning director Spike Lee is directing a new docuseries based on the book Blood in the Garden. To underline the point even further, the team also attached to the tweet a grainy photograph of Lee and Dolan shaking hands at halftime. The duo made it known that they’ve heard the loud buzz around the Knicks, who are now tied with the Hawks and Heat at No. The inciting incident occurred in the run-up to a Knicks home game on Monday night, when a video emerged of Lee being refused entry to his traditional courtside seat at the Garden by arena. The big man - while celebrating the crucial win with LeBron James, who missed the matchup to rest his right ankle - mocked Lee by pretending he couldn’t hear him. What the Knicks can learn from the Nuggets-Heat Finals showdownĪnthony Davis had fun taunting Spike Lee after the Lakers won a physical overtime battle against the Knicks on Tuesday night.įollowing an electric performance at home that left him admittedly “hurting,” Davis relished in the moment when he had a post-game stare-down with Lee. Please disable your ad blocker to view the video content. Knicks shouldn’t make play for this star - as enticing as he isĪn early look at the 2023-24 NBA title odds Ma8:28pm Updated An ad blocker has likely prevented this video content from loading. ![]() Who the Knicks should move on from according to Stephen A Smith ![]() ![]() Newton, on the other hand, has had more big-budget experience with movies like Pokemon: Detective Pikachu, Freaky, and Big Little Lies under her belt. Fuhrmann played only a minor role in Endgame and has mostly been in independent movies, aside from these scenes in one of the biggest movies of all time. Since then, though, Marvel Studios has once again recast the role, this time with Kathryn Newton. ![]() ![]() After the five-year time jump between Avengers: Infinity War and Avengers: Endgame, though, Marvel Studios needed to age Cassie up to match, leading them to cast Emma Fuhrmann in the role. Abby Ryder Fortson played the character in Ant-Man and Ant-Man and the Wasp, portraying Cassie as a pre-teen character. Speaking of three actors, that brings us to Cassie Lang, daughter of Ant-Man Scott Lang. Marvel Studios boss Kevin Feige, meanwhile, said that it was "rooted in the need for an actor who embodies the creativity and collaborative spirit of our other talented cast members." Later, Norton would say that he wanted to take the character in a darker direction than Marvel Studios wanted, but that he "got on great with Kevin Feige." After the Incredible Hulk, Edward Norton had said that he wanted "more diversity" in his career, and not to be stuck playing one character. Interestingly, Ruffalo had been Incredible Hulk director Louis Leterrier's first choice for the character. A decade later, She-Hulk would joke about the casting change when Mark Ruffalo's Bruce Banner says that he feels like a completely different person from when he fought the Abomination in this first movie. The next time we saw the character, though, he was played by Mark Ruffalo. kicked off the MCU with Iron Man, Edward Norton brought us the most authentic-feeling take on the Incredible Hulk yet. The first big recasting in the MCU is, perhaps, also the most dramatic. It happens all the time, but when your movies make up four of the top 10 highest-grossing films of all time, it's just a little more visible. On the CW's Superman & Lois, super-son Jonathan Kent was recast after actor Jordan Elsass left the role to focus on his mental health. Over on Netflix, Liam Hemsworth will replace Henry Cavill as The Witcher's Geralt in Season 4 (though it turns out he auditioned for the role some years ago). Just this fall we have examples of television characters being recast. ![]() The Dark Knight famously swapped Katie Holmes out for Maggie Gyllenhaal for the character of Rachel Dawes. ![]() Fox subbed in and shot his scenes overnight while fulfilling his obligations to his TV show, Family Ties. Back to the Future filmed five weeks of scenes with Eric Stoltz before deeming him a poor fit for the role, and Michael J. The Harry Potter films had to recast Michael Gambon as Dumbledore after actor Richard Harris passed away between the second and third films. Recasting happens all the time in Hollywood, often without us even knowing it, as some of the instances in the following gallery show. Some are nearly invisible, some are conditional, but others are dramatic and impossible to miss. But while it's hard to imagine other actors stepping into their shoes, other characters have been recast-some even more than once-just within the MCU. Jackson seem almost inseparable from Tony Stark and Nick Fury, and Ryan Reynolds has taken ownership of Deadpool in a way few actors do with their roles. When we think of the Marvel Cinematic Universe, one of the first things that comes to mind is the iconic casting for so many characters. ![]() ![]() ![]() And we are seeing a large movement - with respect - to the fiat currency to bitcoin interface, to crypto interface. But I would say there are actually much larger geopolitical fundamentals with the respect to the price for bitcoin itself. So ether purchasing for the purpose of transferring into ICO is definitely an economic driver for that. Matsumura: The most common platform is actually the ethereum blockchain. So all this ICO activity is actually increasing the price of bitcoin Silverstein: And is that one of the things causing bitcoin to go up? To have ICOs you have to use bitcoin. One case - for example - eos has probably estimated about 700 million USD that's been raised as a function of increase in bitcoin and ether. The value of which also continues to rise. And what’s interesting they’re raising it in bitcoin and ether. So we’re seeing companies raise as much as 200 million USD per ICO. Year to date we've seen about 3 billion go into the ICO market. Matsumura: Well we’re seeing about 30 new ICOs launching per day. Silverstein: And how many of these are there? And that’s basically used to buy goods and services in some kind of microeconomy. So it represents the physical or virtual goods of that token. So asset backed is literally what it means, which is there’s real estate back there. There’s really two classes of ICO tokens. ![]() And if that company continues to grow then maybe that coin will increase in value. Silverstein: So the ICO coins associated with those, new ICOs are spurring new companies. Silverstein: So kind of like the bitcoin - the value of the bitcoin is what keeps the bitcoin blockchain going right? So that’s pretty interesting and potentially concerning for people who hold them. Matsumura: One of the big concerns people have about coins and cryptographic tokens is that they don’t actually confer legal rights in most cases. Silverstein: So it’s not like you have a stake in an IPO? You don’t have a stake in what’s behind it? Matsumura: So what you're getting is that you’re getting a cryptographic token to store in a piece of wallet software and ultimately the value is determined by the value of the economy being created by this entity Silverstein: And what are you getting? So you're getting a coin. So essentially what is happening is that tokens are being created and they are being sold to the public. Matsumura: ICO is kind of a funnily named thing. Sara Silverstein: So I really want to learn everything I can from you about ICOs. Miko Matsumura: Hi, I’m Miko Matsumura co-founder of the Evercoin Cryptocurrency Exchange and here’s everything you need to know about initial coin offerings. The following is a transcript of the video. Miko Matsumura, co-founder of the Evercoin Cryptocurrency Exchange, talks with Business Insider executive editor Sara Silverstein about initial coin offerings. Account icon An icon in the shape of a person's head and shoulders. ![]() |
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